Knowing Your Cancer, How Lymphoma Spreads
These are some facts according to the Leukemia & Lymphoma Society: 19.5 out of every 100,000 people in the world develop Non-Hodgkins Lymphoma while 2.8 out of every 100,000 people in the world are diagnosed with Hodgkins disease. Hodgkins disease and Non-Hodgkins Lymphoma are two of the main classifications of lymphoma, a cancer of the bodys lymph system. The lymph system, being part of our immune system, is tasked to eliminate bacteria, diseases and infection from our body. But when the cells multiply abnormally, tumors begin to appear in the lymph nodes. You can feel these as lumps in the nodes of the neck, armpit and groin. Soon the cancer cells will spread in other parts of the body, how lymphoma spreads is a good thing to know.
Metastasis. This is a word we often hear in cancer patients. This is actually a term which refers to the spreading of cancer to the rest of the body. Lymphoma at first is a single tumor in one of the many lymph nodes of the body. What happens when the cancer cells undergo metastasis is that cancer-infected cells break away from the main tumor and moves to another part of the body. The cancer cells use the bloodstream to move from one area of the body to another. The cancer cell can attach itself to another lymph node or to other organs of the body. When it fastened firmly, the cells reproduce again until it creates another mass of tissue to form as a tumor. Then the whole process repeats itself.
For lymphoma, the cancer cells use the lymphatic system of the body to spread. The lymphatic system of the body is pretty much like the bloodstream, it is spread although out the body since it is responsible for keeping the body clean from infections and diseases. The lymphatic system is an open canal where cancer cells can travel and create more tumors.
The tumors are pretty deadly. Because of the accelerated rate of growth, these cancer cells can continue to make the tumors grow. Soon enough the tumors grow large enough that the healthy tissues or organs are prevented to function normally. Eventually the healthy tissues or organs will stop functioning which spells death to the person.
Like any cancer, lymphoma has also a number of stages. These stages describe the severity of the condition and indicate how far the cancer cells have infected the body. Stage I is the first stage of the cancer. At this level, the cancer cells have only infected one lymph node or one part of the body. Because it is still developing, this stage is also referred to as the early disease.
The second stage or Stage II is far more alarming. At this point the cancer cells have metastasis and have infected another one or even more lymph nodes or parts of the body. However, at Stage II the infection is limited to either above or below the persons diaphragm. This stage is called locally advanced disease.
Stage III is known as the advanced disease. The cancer cells at this stage have found its way on both sides of the diaphragm and have established a number of tumors in those areas. The final stage or Stage IV or widespread disease is described by spread of the cancer cells to one or more of the bodys organs such as the bone, skin, liver or lungs.
This is how lymphoma spreads. That is why it is important for an early detection of the disease for proper and effective treatment.
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How Does One Get Lymphoma?
Lymphoma is a type of cancer that affects the bodys lymph system. Contrary to its name and to what some people might have told you, lymphoma is not just isolated on the lymph nodes and thymus gland for the lymph or lymphatic system is actually composed of the bone marrow, the thymus gland, the lymph nodes, tonsils, appendix and spleen. The system filters the waste or unwanted materials like fats and bacteria from the various body tissues. The one that picks up the bodys dirt is the lymph, a clear or sometimes yellowish fluid. But the question remains, how does one get lymphoma?
Unfortunately however, the answer to that question is not a simple one. For one, despite the thousands of hours spent on medical research and laboratory testing the actual cause of the disease is still an unknown. DNA mutation is one of the possible cause of why lymphoma develops but what happens why DNA have to mutate remains a big question to the medical science community. Medical scientists, nevertheless, have found several factors that can possibly increase the risks of developing lymphoma.
As you might have already guessed, the two general factors are genetic and environmental factors. Genetics for one is still a complicated issue that most likely cannot be resolved soon with a concluding answer. Inheriting the disease cannot still be ascertained as a valid cause. However, it was found out the people with inherited immune disorders are most likely to develop lymphoma as well. Immune disorders such as lupus, rheumatoid arthritis and celiac disease appear to have a hand in the development of lymphoma.
Likewise, those that have immune system disorders are also at a higher risk of developing lymphoma. Those that belong to this type of disorders include patients with HIV/AIDS, Helicobacter Pylori and Epstein-Barr virus (EBV). People with compromised immune systems like those with HIV/AIDS and EBV are often candidates for lymphoma as well.
On the environmental factors side, it should be common knowledge by now that various health hazards such as exposure to chemicals and radiation causes a variety of diseases, disorders or health conditions. And this includes developing lymphoma. More specifically, solvents like acetone, alcohol (yes various alcohols), xylene, turpentine, and benzene have found to associated with lymphoma.
The same can be said with chemical herbicides and pesticides which make farmers and various workers in the agricultural sector at a higher risk on developing the disease. Some hair dye products have also been found to be a significant factor to the development of lymphoma in some patients. Although, it seems that the hair dye products that shown such effects were those manufactured before the 1980s.
How does one get lymphoma? To fully answer that question means giving more time and more funding to the medical science community to do their research and testing. Lymphoma cases are not going down and definitely the disease is not something that can be eradicated in a quick span of time. But for now, we should at least try to avoid the various factors that increase our risk of contracting the disease. Prevention is still the best cure.
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Diagnosing Lymphoma
Many people that suffer from lymphoma, the cancer of the lymph system, remain undiagnosed for a long time because they dont know the symptoms to watch out for.
The alarming signs of lymphoma would include enlarged nodes that are usually painless lumps that are seen in the neck, armpits or groin; sudden dropping of weight; continuous or internment fever, excessive sweating at night time, extreme itchiness every part of the body, the rapid loss in appetite; the feeling exhaustion or fatigue, weakness despite regular eating and rest, and swollen neck and face along with non stop breathlessness.
Aside from the lymph system, experts say that lymphoma can also occur in the other parts of the body or organs such as the stomach. So, when at least three of these symptoms become persistent, it would be best for you to consult a doctor so he or she could request for lymphoma diagnosis for you.
Options for lymphoma diagnosis
If you want to have an idea what are the options for you when you decide to undergo diagnosis for lymphoma, the most common tests and procedures would include biopsy, knowing the type of lymphoma and other related tests.
1. Biopsy. This is considered as the “first step” in diagnosis for lymphoma. Usually, doctors perform what they call “excisional biopsy” wherein a small sample of tissue will be acquired from the affected organs or nodes of the patient. Once the sample is acquired, an expert called “pathologist,” will examine it under the microscope. Here, it can be seen if the patient has cancer cells that would cause lymphoma. The most common type of biopsy given to those who are at risk is “lymph node biopsy”. However, when the cancerous cells affect areas such as the brain, the skin, or the abdomen or stomach, a biopsy from the mentioned organ will be prioritized. A more specific type of biopsy for lymphoma is called “Lymph Node Biopsy and Fine Needle Aspiration Cytology” or FNAC which intends to get more sample for to produce a well-detailed diagnosis.
2. How to determine the type of lymphoma. Once the biopsy has been made, the next would be how to determine the type of lymphoma there is. There are over 20 types of lymphoma but these all fall under two category including Hodgkin or non-Hodgkin lymphoma. This can be determined by the pathologist once he or she places the sample of tissue under a microscope. Here, physical appearance of the cells will be scrutinized carefully.
3. Succeeding tests after the diagnosis. After the biopsy and after the type of lymphoma has been determined, a series of tests and other examinations will follow. These are very important to be able to know exactly how much of the cancer cells have spread out and the potential damage it has brought to the organ/s affected. Other tests might include Bone Marrow Test and PET Scans for Lymphoma among others. These are crucial for the patient so he or she would undergo necessary treatments that would make the condition a lot better.
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What is Lymphoma?
Lymphoma is simply defined as a type of cancer in the lymph system. British physician Thomas Hodgkin was the first to publish initial descriptions of the condition in 1832. Thus, the specific type of lymphoma he described (Hodgkins lymphoma) was appropriately named after him. After his initial description, many other studies looked at several other forms or types of the cancerous disease.
A cancer appears when several of our bodies cells begin behaving abnormally. The body is comprised of various kinds of cells found in different organs like the nerves of blood. At times, normal cells cease getting usual biological signals that make them stop growing. When that happens, the cells abnormally continue to multiply and grow. This is the formation of cancer cells. When the cancer cells grow, the affected organ stops working normally. Several of the cancer cells also start to break off from the original site, spreading into many other body parts and affecting many other organs.
The lymph system comprises an interconnected network with thin nodes and tubes carrying white blood cells. Such cells are responsible for fighting off infections. This way, they are vitally significant to the bodys overall well-being. When a lymphocyte (a specific kind of white blood cell) in the lymph system starts to become cancerous, it would tend to multiply and grow leading to formation of lymphoma.
Which part of the body is usually affected by lymphoma? The cancer could affect any part of the lymph system. Usually, patients initially notice abnormal enlargement of the lymph nodes, specifically in the areas of the groin, the neck, and the armpits. However, lymphoma could also manifest in several other organs of the body. This is because minimal amounts of lymph tissue pass into practically every organ in the body as white blood cells reach out to different areas to perform control of infections.
This type of cancer is currently the most usual form of blood cancer or hematological malignancy especially in the developed countries. Lymphoma comprises about 5.3% of overall forms of cancers in the United States alone. It comprises of up to 55.6% of blood cancers diagnosed. According to data released by the US National Institute of Health, Hodgkins lymphoma is accounting for about 1% of total cases of cancer across the country. Patients with HIV infection and exposure to certain medications and drugs have higher incidences of lymphoma for obvious reasons.
Many forms of lymphoma are indolent (occurring lifelong even without medication or treatment) or aggressive (causing fast deterioration of health and eventually death). However, most incidences of aggressive lymphomas are responding ideally to treatment. In other words, they are curable. This condition is not a single type of cancer because it comprises of a group of several related forms of cancers. There are about 30 various types of identified lymphoma. In a broad sense, lymphoma could be categorized as either Hodgkin or Non-Hodgkin lymphoma. Of course, each type has its own features and manifestations and results to different outcomes in the long term.
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