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The Types of Non-Hodgkins Lymphoma

Lymphomas are cancers of the lymph system which ironically is part of the bodys defense mechanism to fight off infections and diseases. But sometimes the abnormal growth of the healthy lymphatic cells causes the tissues to mass up creating tumors and eventually becoming cancer cells. If left untreated, the cancer cells can easily break away from the tissues and begin infecting other parts of the lymphatic system and eventually moving to other organs of the body. There are essentially two kinds of lymphomas, the Hodgkins lymphoma and non-Hodgkins lymphoma.

Hodgkins lymphoma is characterized by the presence of Reed-Sternberg cells. Other lymphomas do not contain these cells so the rest of the lymphomas were classified as non-Hodgkin’s lymphoma or NHL. There are a number of sub-types of non-Hodgkin’s lymphoma. Each are quite distinct targeting specific age groups aside from having unique forms.

One kind of NHL is the lymphoblastic lymphoma or LBL which commonly occurs in children. In fact about 30% of documented cases of lymphomas in children have been classified as lymphoblastic lymphomas. LBL is very aggressive kind of NHL and has caused quite a number of deaths in the past. But because of modern medicine and treatment techniques, LBL patients have better odds of surviving the ordeal.

Unlike LBL, the diffuse histiocytic lymphoma type or DHL is a slow growing cancer. And because it is slow-growing the cancer is quite hard to detect. Also, there are times where the cancer reappears after treatment.

Another kind of NHL appears closer to the bodys surface. The cutaneous T-cell lymphoma or CTLC is a kind of lymphoma that affects the skin. What happens is that the white blood cells of the skin become cancerous. At first, the signs are dry, scaly skin with red or dark patches. These areas of the skin also itch a lot. But as the cancer cells continue to grow, the skin will develop highly noticeable tumors. Eventually the cancer cells enter the blood stream and spreads all over the body which soon infects other tissues and organs.

Although not common, the mantle cell lymphoma is another kind of non-Hodgkin’s lymphoma. This cancer borders on being rare since only an estimated 5% of people diagnosed with NHL have it. It seems that the cancer is more likely to occur in men 50 years old and older. The cancer starts off as a slow growing lymphoma but can suddenly become aggressive in later stages.

Doctors have made 4 classifications or stages of non-Hodgkin’s lymphoma which basically indicates how fast and how far the cancer cells have spread. Stage 1 is when the cancer cells are grouped in lymph node or organ of the body. In stage 2 the cancer has spread to two or more groups of lymph nodes or organs on the same side of your diaphragm. Stage 3 is where the cancer cells have infected organs on both sides of the diaphragm and finally stage 4 is when the different types of non-Hodgkins lymphoma have gone beyond the lymphatic system and infecting other organs like the liver, bones, and lungs.


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Knowing Your Cancer, Hodgkins disease

Hodgkin’s lymphoma or otherwise known as Hodgkin’s disease is one of two kinds of lymphoma or a cancer of the lymphatic system. Thomas Hodgkin was the first person who published documented studies of the disease hence the cancer was named after him. Hodgkin’s lymphoma is different from the other kind of lymphoma mainly through the presence of Reed-Sternberg cells in the cancer cells. These Reed-Sternberg cells can be seen through an open biopsy. In contrast, cells seen on non-Hodgkins lymphomas are mutated B-cells or T-cells.

It has been observed that Hodgkins lymphoma oftentimes begin to develop in the lymph nodes in the neck. This is again quite different from non-Hodgkins lymphoma which beings in different locations in the body. Nonetheless, since this is cancer were talking about, from the neck lymph node spreading to other lymph node groups, the lungs, spleen, and bone marrow is only natural and inevitable if no treatment is undergone. It seems also that Hodgkin’s lymphoma targets the immediate nearby lymphatic regions before leaving eventually the lymphatic system and spreading throughout other organs of the body.

According to studies, Hodgkins lymphoma is more likely to develop in young adolescents particularly those within the age range of 15 to 24 as well as those who are more than 60 years old. Again this is quite different from non-Hodgkins lymphoma which rarely happens in young people and instead is more common to people aged 60 years old and above.

In determining a diagnosis, one can actually self-diagnose at least initially. A doctors expertise is still needed, of course, for a more accurate diagnosis of the disease. The symptoms that have been reported are not that different from the other kinds of lymphoma. The presence of a painless lump in the lymph nodes in the neck, underarm, or groin, recurrent fevers, unexplained weight loss, night sweats and itchy skins are among the warning signals of developing lymphoma.

Among the usual tests your doctors would require you to undertake includes blood tests to check abnormalities in the blood counts, blood chemistry, and abnormal erythrocyte sedimentation rate (ESR), X-rays to look at the lymph nodes, computerized tomography or CT scan and magnetic resonance imaging or MRI scans of the chest, pelvis, and abdomen to see if the cancer has already spread to other parts of the body.

Other scans that could be used to properly diagnose and determine the stage of the cancer are the positron emission tomography or PET scan which scans the cancer at a cellular level and the gallium scan which looks for radioactive intake of gallium which can mean the onset of the disease. There are other tests and procedures which doctors might conduct on you all in the aid of a proper and accurate diagnosis.

Hodgkins lymphoma has several sub-types, namely nodular sclerosis (NS) which hits the lower neck, chest and collarbone, lymphocyte predominance (LP) which is made of malignant L&H cells which have a “popcorn”, mixed cellularity (MC) which has lymph nodes that are usually contain Reed-Sternberg cells and inflammatory cells, lymphocyte depleted (LD), and nodular lymphocyte predominant (NLP).

As they say, knowing is half the battle. Knowing more about Hodgkins disease is a good thing. You can contribute fully to the decision making process if you know exactly the situation you are in.


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All You Need to Know About Lymphoma

Whenever you get sick, whats the first thing that you do? Know what you have. Either its a simple fever or a complicated illness, the very first thing that you do is to gather information to find out your current condition. The same thing with lymphoma, whether you research things on your own or go to a doctor (although this should always be the case since self diagnosis can bring you only so far) for advice, your target is to get all you need know about the disease.

Lymphoma is basically a cancer of the lymphatic system. The system is composed of various nodes or glands situated in different places of our body. These glands are connected by vessels that carry the lymph fluid or the white blood cells which help fight diseases. As you might have remembered in your high school biology class, the white blood cells help fight the bacteria and diseases that enter our body. And because these glands are connected to each other, once lymphoma hits a gland, theres a good chance that the cancer cells spread throughout the body via the lymph vessels. You should know this fact out front: no cure has been discovered yet that would eliminate the disease. Nonetheless, there are new techniques, medicines and medical procedures that have brought more positive treatments for people with lymphoma.

There are two kinds of lymphoma, namely Hodgkin’s lymphoma and Non Hodgkin’s lymphoma (NHL). The first one, the Hodgkins disease owes its name to Thomas Hodgkin (1798-1866). He was the first one who published a paper about the disease. This kind of lymphoma is capable of spreading from one lymph node to another. It is also observed that people diagnosed with Hodgkins lymphoma has the presence of Reed-Sternberg cells which can only be detected by the aid of a microscope.

The other kind of lymphoma is the non-Hodgkin kind. This kind is described as having larger than normal lymph nodes and is accompanied by fever and weight loss. There are about 16 sub-types which do not fall under the conditions described by Hodgkins lymphoma. These sub-types are grouped according to aggressiveness which basically means the cancer cells are fast-growing. NHL lymphomas include chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), Burkitt lymphoma, mantle cell lymphoma, follicular lymphoma, diffuse large B-cell lymphoma and immunoblastic large cell lymphoma.

Treatment is either radiation therapy or chemotherapy. The age, sex and stage of the cancers development plays a role in determining the kind of treatment patients will undergo. Early detection is crucial. Most of the patients do survive the treatment especially if they have been diagnosed during the early stages of the lymphoma.

Some of the more common symptoms of lymphomas include painless swelling in the lymph nodes of the neck, underarm, or groin. People with lymphomas also might experience fever, tiredness, weight loss, itchiness, red patches on the skin, nausea, vomiting and sometimes abdominal pain.

Those with low-grade lymphomas will encounter a very slow growth of the cancer cells and will experience very few of the symptoms. The problem with low-grade lymphomas is that even though they respond well to chemotherapy, they oftentimes return and is considered incurable unlike high-grade lymphomas. With the latter, treatment involves chemotherapy, with or without radiation therapy.

Admittedly, the information above is not all that you need to know about lymphoma. There are more facts that you need to find out for yourself especially if you have been diagnosed with having lymphoma.


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